KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEFL
All Species:
0
Human Site:
S221
Identified Species:
0
UniProt:
P07196
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07196
NP_006149.2
543
61517
S221
D
S
L
M
D
E
I
S
F
L
K
K
V
H
E
Chimpanzee
Pan troglodytes
Q5R1W8
466
53634
E198
E
E
M
L
Q
R
E
E
A
E
N
T
L
Q
S
Rhesus Macaque
Macaca mulatta
XP_001107100
543
61468
A221
D
S
L
M
D
E
I
A
F
L
K
K
V
H
E
Dog
Lupus familis
XP_534572
544
61513
A221
D
S
L
M
D
E
I
A
F
L
K
K
V
H
E
Cat
Felis silvestris
Mouse
Mus musculus
P08551
543
61490
A221
D
S
L
M
D
E
I
A
F
L
K
K
V
H
E
Rat
Rattus norvegicus
P19527
542
61317
A221
D
S
L
M
D
E
I
A
F
L
K
K
V
H
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516217
551
61697
A229
D
S
L
V
D
E
M
A
F
L
K
K
V
H
E
Chicken
Gallus gallus
P16053
858
95817
A227
Q
S
L
Q
D
E
V
A
F
L
R
G
N
H
E
Frog
Xenopus laevis
P35616
544
61843
A215
D
S
L
L
D
E
I
A
F
L
K
K
V
H
E
Zebra Danio
Brachydanio rerio
Q58EE9
444
51231
E178
T
A
L
R
Q
E
A
E
N
N
L
N
T
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
37.7
99.6
98.3
N.A.
95.5
95.9
N.A.
81.8
33.5
70
37.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
58.2
100
98.9
N.A.
97.7
98.1
N.A.
88.7
46.3
85.6
55
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
93.3
93.3
N.A.
93.3
93.3
N.A.
80
53.3
86.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
100
73.3
100
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
10
70
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
70
0
0
0
80
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
10
0
0
0
90
10
20
0
10
0
0
0
0
80
% E
% Phe:
0
0
0
0
0
0
0
0
80
0
0
0
0
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
80
0
% H
% Ile:
0
0
0
0
0
0
60
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
70
70
0
0
0
% K
% Leu:
0
0
90
20
0
0
0
0
0
80
10
0
10
0
0
% L
% Met:
0
0
10
50
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
10
10
10
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
10
0
0
10
20
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
10
0
10
0
0
0
0
10
0
0
0
10
% R
% Ser:
0
80
0
0
0
0
0
10
0
0
0
0
0
0
10
% S
% Thr:
10
0
0
0
0
0
0
0
0
0
0
10
10
0
0
% T
% Val:
0
0
0
10
0
0
10
0
0
0
0
0
70
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _